Ca-Antagonists and Atherosclerosis

Atherosclerosis, calcium, and calcium antagonists.

Differences in Cardioprotective Efficacy of Adrenergic Receptor Antagonists and Ca 21 Channel Antagonists in an Animal Model of Dilated Cardiomyopathy

(Fz-DCM). whether five cardioactive agents were cardioprotective in this model of heart failure, ie, they prevented dilatation and wall thinning and improved contractile performance. We compared the effects of chronic administration of af,3-selective and a nonselective 3-receptor antagonist, a-receptor antagonist, two Ca2' channel antagonists in the presence of Fz administration. The greatest c...

Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists

Myocardial cells have two types of Ca channels commonly called T-type and L-type. Whole cell Ca channel currents in guinea pig atrial myocytes can be separated and quantitated by analyzing channel closing kinetics after a brief depolarization (tail current analysis). L-type Ca channels deactivate rapidly when the membrane is repolarized and T-type Ca channels deactivate relatively slowly. Ca ch...

Effects of Organic Antagonists of Ca, Na, and K on Chemotaxis and Motility of Escherichia coli

Various Ca antagonists used in animal research, many of them known to be Ca channel blockers, inhibited Escherichia coli chemotaxis (measured as entry of cells into a capillary containing attractant). The most effective of these, acting in the nanomolar range, was v-conotoxin GVIA. The next most effective were gallopamil and verapamil. At concentrations around 100-fold higher than that needed f...

Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca and nonselective cation channels

Weigand, Letitia, Joshua Foxson, Jian Wang, Larissa A. Shimoda, and J. T. Sylvester. Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca and nonselective cation channels. Am J Physiol Lung Cell Mol Physiol 289: L5–L13, 2005. First published February 18, 2005; doi:10.1152/ajplung.00044.2005.—Previous studies indicated that acute hypoxia increased intracellular Ca...